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Open Targets Platform
Open Targets scores how strongly each gene is linked to each disease, with the evidence behind it.
Overview
The Open Targets Platform scores how strongly each gene is linked to each disease and exposes the evidence behind the score, integrating genetics, expression, literature and drug data into target-disease associations. It also carries ChEMBL drug data, safety liabilities, tractability assessments and the Open Targets Genetics results. The platform is a partnership of EMBL-EBI, the Wellcome Sanger Institute, GSK, Sanofi, BMS, Pfizer and Genentech, released as open data under CC0. On OnCo it is filed under AI-driven drug and target discovery and is cited by the bottlenecks The undruggable drivers, No incentive to repurpose cheap drugs and The valley of death between lab and product, and by ideas such as A target de-risking index that counts failures as well as successes.
Holds
Target-disease association evidence integrating genetics, expression, literature, and drugs.
Licence
CC0 / open
Maintainer
EMBL-EBI, Sanger, GSK, Sanofi, BMS, Pfizer, Genentech
Dataset registry
Size: Target-disease evidence for about 60,000 targets
Access: open
Consent and reuse: CC0 and per-source licences.
All datasets and the models trained on them →Similar pages
- CancerSkin cancer (all types)
- CancerBreast cancer (all types)
- CollectionCIViC
- CancerNon-Hodgkin lymphoma (all types)
- CancerLeukaemia (all types)
- CancerLung cancer (all types)
- CancerColorectal cancer
- CancerProstate cancer
technologies
targets
institutions
ideas
A pre-competitive consortium to validate or kill academic targets before licensingA registry for preclinical experiments that did not workA target de-risking index that counts failures as well as successesAn annual map of high-burden questions that nobody is fundingAn open knowledge graph linking trials, results, biomarkers, drugs and recommendationsPre-registered, publicly scored AI ranking of repurposing candidates for cancer
collections
bottlenecks
Open-source projects
All open source in oncology →Open-source projects that are the code behind this collection or publish it, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
The React front end of the Open Targets Platform.
The EMBL-EBI, Sanger and pharma partnership's open platform for target identification and prioritisation, with open data downloads and APIs.