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APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.24, somatic mutation 0.95).
In plain words · APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms.
No product in this corpus aims at APOBEC3B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1999. Earliest sequence paper UniProt cites for the protein: Madsen P.P. et al, J. Invest. Dermatol, 1999, "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1". Source.
Sources: HGNC HGNC:17352 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UH17 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179750 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.50 (GraphQL API, CC0))
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukaemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Location: Nucleus (UniProt). Locus 22q13.1 (HGNC).
Query for this target: (TITLE:"APOBEC3B" OR ABSTRACT:"APOBEC3B" OR TITLE:"apolipoprotein B mRNA editing enzyme catalytic subunit 3B" OR ABSTRACT:"apolipoprotein B mRNA editing enzyme catalytic subunit 3B" OR TITLE:"DNA dC->dU-editing enzyme APOBEC-3B" OR ABSTRACT:"DNA dC->dU-editing enzyme APOBEC-3B" OR TITLE:"PHRBNL" OR ABSTRACT:"PHRBNL" OR TITLE:"FLJ21201" OR ABSTRACT:"FLJ21201") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APOBEC3B, not a curated reading list.