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APOE (Apolipoprotein E) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.99, animal model 0.50, genetic association 0.67).
In plain words · APOE (Apolipoprotein E) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
APOE (Apolipoprotein E) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.
No product in this corpus aims at APOE yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1982. Earliest sequence paper UniProt cites for the protein: Breslow J.L. et al, J. Biol. Chem, 1982, "Identification and DNA sequence of a human apolipoprotein E cDNA clone". Source.
Sources: HGNC HGNC:613 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02649 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130203 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells. Location: Secreted; Secreted, extracellular space; Secreted, extracellular space, extracellular matrix; Extracellular vesicle (UniProt). Locus 19q13.32 (HGNC).
Query for this target: (TITLE:"APOE" OR ABSTRACT:"APOE" OR TITLE:"apolipoprotein E" OR ABSTRACT:"apolipoprotein E" OR TITLE:"Apolipoprotein E" OR ABSTRACT:"Apolipoprotein E" OR TITLE:"AD2" OR ABSTRACT:"AD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APOE, not a curated reading list.