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ADRA2B (Alpha-2B adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.11, animal model 0.43, clinical 0.81).
In plain words · ADRA2B (Alpha-2B adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
ADRA2B (Alpha-2B adrenergic receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression.
No product in this corpus aims at ADRA2B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ADRA2B: RNA low tissue specificity; high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ADRA2B tissue; Open Targets ENSG00000274286 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Lomasney J.W. et al, Proc. Natl. Acad. Sci. U.S.A, 1990, "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2". Source.
Sources: HGNC HGNC:282 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18089 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000274286 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Location: Cell membrane (UniProt). Locus 2q11.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Soft tissue, Testis.
No cancer stained high; medium in prostate cancer, thyroid cancer.
HPA ADRA2B tissue · HPA ADRA2B pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ADRA2B" OR ABSTRACT:"ADRA2B" OR TITLE:"adrenoceptor alpha 2B" OR ABSTRACT:"adrenoceptor alpha 2B" OR TITLE:"Alpha-2B adrenergic receptor" OR ABSTRACT:"Alpha-2B adrenergic receptor" OR TITLE:"ADRARL1" OR ABSTRACT:"ADRARL1" OR TITLE:"ADRA2L1" OR ABSTRACT:"ADRA2L1" OR TITLE:"ADRA2RL1" OR ABSTRACT:"ADRA2RL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADRA2B, not a curated reading list.