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AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, animal model 0.46, genetic association 0.00, somatic mutation 0.84). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Lung Adenocarcinoma, Well-Differentiated Thyroid Cancer.
In plain words · AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
AFF3 (AF4/FMR2 family member 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Thyroid cancer, Skin cancer and 4 more.
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
No product in this corpus aims at AFF3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Ma et al, Blood, 1996, "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Source.
Sources: HGNC HGNC:6473 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51826 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000144218 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: gastric cancer 0.52, skin cancer 0.55, breast cancer 0.58, lung cancer 0.55 (GraphQL API, CC0)); IntOGen AFF3 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. Location: Nucleus (UniProt). Locus 2q11.2 (HGNC).
Query for this target: (TITLE:"AFF3" OR ABSTRACT:"AFF3" OR TITLE:"ALF transcription elongation factor 3" OR ABSTRACT:"ALF transcription elongation factor 3" OR TITLE:"AF4/FMR2 family member 3" OR ABSTRACT:"AF4/FMR2 family member 3" OR TITLE:"MLLT2-like" OR ABSTRACT:"MLLT2-like" OR TITLE:"LAF4" OR ABSTRACT:"LAF4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AFF3, not a curated reading list.
Shares Thyroid cancer, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Thyroid cancer, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Thyroid cancer, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Thyroid cancer, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Thyroid cancer, Skin cancer (all types), IntOGen, Gastric & gastro-oesophageal junction cancer.
Shares Thyroid cancer, Lung cancer (all types), Open Targets Platform, Non-small-cell lung cancer.