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CUX1 (Homeobox protein cut-like 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Breast cancer and 5 more.
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis.
Open Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.96, genetic association 0.67, somatic mutation 0.88, animal model 0.69). IntOGen calls it a driver in 7 cohorts (2 activating, 5 loss-of-function), covering Invasive Breast Carcinoma, Glioblastoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma, Pancreatic Adenocarcinoma and others.
In plain words · CUX1 (Homeobox protein cut-like 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Breast cancer and 5 more.
CUX1 (Homeobox protein cut-like 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Breast cancer and 5 more.
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III.
No product in this corpus aims at CUX1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1992. Earliest sequence paper UniProt cites for the protein: Neufeld E.J. et al, Nat. Genet, 1992, "Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut". Source.
Sources: HGNC HGNC:2557 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P39880 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000257923 (association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: colorectal cancer 0.50, gastric cancer 0.50, melanoma 0.61, acute lymphoblastic leukaemia 0.57, non-Hodgkin lymphoma 0.58, skin cancer 0.67 (GraphQL API, CC0)); IntOGen CUX1 (driver in 7 cohorts (Act 2, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Location: Nucleus (UniProt). Locus 7q22.1 (HGNC).
Query for this target: (TITLE:"CUX1" OR ABSTRACT:"CUX1" OR TITLE:"cut like homeobox 1" OR ABSTRACT:"cut like homeobox 1" OR TITLE:"Homeobox protein cut-like 1" OR ABSTRACT:"Homeobox protein cut-like 1" OR TITLE:"CDP1" OR ABSTRACT:"CDP1" OR TITLE:"Clox" OR ABSTRACT:"Clox" OR TITLE:"CDP/Cut" OR ABSTRACT:"CDP/Cut") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CUX1, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Thyroid cancer, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).