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NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Lung Squamous Cell Carcinoma.
In plain words · NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more.
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC.
No product in this corpus aims at NUP98 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1996. Earliest sequence paper UniProt cites for the protein: Borrow et al, Nat. Genet, 1996, "The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9". Source.
Sources: HGNC HGNC:8068 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P52948 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110713 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.55, breast cancer 0.52, lung cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)); IntOGen NUP98 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localisation of DHX9 in discrete intranuclear foci (GLFG-body). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). Location: Nucleus membrane; Nucleus, nuclear pore complex; Nucleus, nucleoplasm (UniProt). Locus 11p15.4 (HGNC).
Query for this target: (TITLE:"NUP98" OR ABSTRACT:"NUP98" OR TITLE:"nucleoporin 98 and 96 precursor" OR ABSTRACT:"nucleoporin 98 and 96 precursor" OR TITLE:"Nuclear pore complex protein Nup98-Nup96" OR ABSTRACT:"Nuclear pore complex protein Nup98-Nup96" OR TITLE:"NUP96" OR ABSTRACT:"NUP96" OR TITLE:"Nup98-Nup96" OR ABSTRACT:"Nup98-Nup96" OR TITLE:"Nup98-96" OR ABSTRACT:"Nup98-96") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUP98, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Melanoma.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).