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CBFA2T3 (Transcriptional corepressor CBFA2T3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer, Lung cancer and 2 more.
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.85, animal model 0.49, genetic association 0.52, somatic mutation 0.97).
In plain words · CBFA2T3 (Transcriptional corepressor CBFA2T3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer, Lung cancer and 2 more.
CBFA2T3 (Transcriptional corepressor CBFA2T3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer, Lung cancer and 2 more.
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes.
No product in this corpus aims at CBFA2T3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1998. Earliest sequence paper UniProt cites for the protein: Gamou et al, Blood, 1998, "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family". Source.
Sources: HGNC HGNC:1537 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75081 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000129993 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: skin cancer 0.51, myeloproliferative neoplasm 0.50, breast cancer 0.52, lung cancer 0.52, leukaemia 0.54 (GraphQL API, CC0))
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Golgi apparatus membrane (UniProt). Locus 16q24.3 (HGNC).
Query for this target: (TITLE:"CBFA2T3" OR ABSTRACT:"CBFA2T3" OR TITLE:"CBFA2/RUNX1 partner transcriptional co-repressor 3" OR ABSTRACT:"CBFA2/RUNX1 partner transcriptional co-repressor 3" OR TITLE:"Transcriptional corepressor CBFA2T3" OR ABSTRACT:"Transcriptional corepressor CBFA2T3" OR TITLE:"MTGR2" OR ABSTRACT:"MTGR2" OR TITLE:"ZMYND4" OR ABSTRACT:"ZMYND4" OR TITLE:"MTG16" OR ABSTRACT:"MTG16") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CBFA2T3, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Breast cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Breast cancer (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Lung cancer (all types), Breast cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.