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ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.18, somatic mutation 0.97).
In plain words · ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
No product in this corpus aims at ETNK1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 2001. Earliest sequence paper UniProt cites for the protein: Lykidis et al, J. Biol. Chem, 2001, "Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway". Source.
Sources: HGNC HGNC:24649 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HBU6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000139163 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.51, breast cancer 0.51, leukaemia 0.52 (GraphQL API, CC0))
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Location: Cytoplasm (UniProt). Locus 12p12.1 (HGNC).
Query for this target: (TITLE:"ETNK1" OR ABSTRACT:"ETNK1" OR TITLE:"ethanolamine kinase 1" OR ABSTRACT:"ethanolamine kinase 1" OR TITLE:"Ethanolamine kinase 1" OR ABSTRACT:"Ethanolamine kinase 1" OR TITLE:"EKI1" OR ABSTRACT:"EKI1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETNK1, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Breast cancer (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Breast cancer (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.