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SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.00, somatic mutation 0.74, genetic literature 0.87).
In plain words · SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
Required for the assembly of mature ribosomes and ribosome biogenesis.
No product in this corpus aims at SBDS yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Lai C.-H. et al, Genome Res, 2000, "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Source.
Sources: HGNC HGNC:19440 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y3A5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126524 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.60, myeloproliferative neoplasm 0.60, leukaemia 0.62 (GraphQL API, CC0))
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Location: Cytoplasm; Nucleus, nucleolus; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 7q11.21 (HGNC).
Query for this target: (TITLE:"SBDS" OR ABSTRACT:"SBDS" OR TITLE:"SBDS ribosome maturation factor" OR ABSTRACT:"SBDS ribosome maturation factor" OR TITLE:"Ribosome maturation protein SBDS" OR ABSTRACT:"Ribosome maturation protein SBDS" OR TITLE:"CGI-97" OR ABSTRACT:"CGI-97" OR TITLE:"FLJ10917" OR ABSTRACT:"FLJ10917" OR TITLE:"SDO1" OR ABSTRACT:"SDO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SBDS, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute myeloid leukaemia, Open Targets Platform.