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RPS29 (Small ribosomal subunit protein uS14) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia and Myeloproliferative neoplasms.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.31, clinical 0.11, genetic literature 0.76).
In plain words · RPS29 (Small ribosomal subunit protein uS14) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia and Myeloproliferative neoplasms.
RPS29 (Small ribosomal subunit protein uS14) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia and Myeloproliferative neoplasms.
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
No product in this corpus aims at RPS29 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists RPS29 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS29: RNA low tissue specificity; high antibody staining in 12 normal tissues; highest cancer staining colorectal cancer (2 of 10 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Myeloid neoplasms); Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RPS29 tissue; Open Targets ENSG00000213741 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Frigerio J.-M. et al, Biochim. Biophys. Acta, 1995, "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Source.
Sources: HGNC HGNC:10419 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62273 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000213741 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.52, leukaemia 0.53 (GraphQL API, CC0))
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 14q21.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Bone marrow, Bronchus, Caudate, Cerebellum, Cervix, Duodenum.
Medium only: breast cancer, cervical cancer, endometrial cancer, glioma.
HPA RPS29 tissue · HPA RPS29 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPS29" OR ABSTRACT:"RPS29" OR TITLE:"ribosomal protein S29" OR ABSTRACT:"ribosomal protein S29" OR TITLE:"Small ribosomal subunit protein uS14" OR ABSTRACT:"Small ribosomal subunit protein uS14" OR TITLE:"S29" OR ABSTRACT:"S29" OR TITLE:"uS14" OR ABSTRACT:"uS14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS29, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.