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ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
In plain words · ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt).
No product in this corpus aims at ACTA2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1984. Earliest sequence paper UniProt cites for the protein: Ueyama et al, Mol. Cell. Biol, 1984, "Structure of a human smooth muscle actin gene (aortic type) with a unique intron site". Source.
Sources: HGNC HGNC:130 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62736 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107796 (per-cancer scores at or above 0.5: leukaemia 0.53 (GraphQL API, CC0))
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 10q23.31 (HGNC).
Query for this target: (TITLE:"ACTA2" OR ABSTRACT:"ACTA2" OR TITLE:"actin alpha 2, smooth muscle" OR ABSTRACT:"actin alpha 2, smooth muscle" OR TITLE:"Actin, aortic smooth muscle" OR ABSTRACT:"Actin, aortic smooth muscle" OR TITLE:"ACTSA" OR ABSTRACT:"ACTSA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTA2, not a curated reading list.