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LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.83, affected pathway 0.94, genetic association 0.37).
In plain words · LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA.
No product in this corpus aims at LRRFIP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1998. Earliest sequence paper UniProt cites for the protein: Reed A.L. et al, J. Biol. Chem, 1998, "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". Source.
Sources: HGNC HGNC:6702 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q32MZ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124831 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0))
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signalling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Location: Nucleus; Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
Query for this target: (TITLE:"LRRFIP1" OR ABSTRACT:"LRRFIP1" OR TITLE:"LRR binding FLII interacting protein 1" OR ABSTRACT:"LRR binding FLII interacting protein 1" OR TITLE:"Leucine-rich repeat flightless-interacting protein 1" OR ABSTRACT:"Leucine-rich repeat flightless-interacting protein 1" OR TITLE:"FLAP-1" OR ABSTRACT:"FLAP-1" OR TITLE:"FLIIAP1" OR ABSTRACT:"FLIIAP1" OR TITLE:"GCF-2" OR ABSTRACT:"GCF-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRRFIP1, not a curated reading list.