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BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Open Targets scores its association with cancer at 0.48 (direct and indirect evidence; datatypes literature 0.97, animal model 0.43, genetic association 0.59).
In plain words · BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
BAK1 (Bcl-2 homologous antagonist/killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM.
No product in this corpus aims at BAK1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Farrow S.N. et al, Nature, 1995, "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K". Source.
Sources: HGNC HGNC:949 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16611 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000030110 (association with cancer (MONDO_0004992) 0.48; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.51, leukaemia 0.51 (GraphQL API, CC0))
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilisation by oligomerising to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Location: Mitochondrion outer membrane (UniProt). Locus 6p21.31 (HGNC).
Query for this target: (TITLE:"BAK1" OR ABSTRACT:"BAK1" OR TITLE:"BCL2 antagonist/killer 1" OR ABSTRACT:"BCL2 antagonist/killer 1" OR TITLE:"Bcl-2 homologous antagonist/killer" OR ABSTRACT:"Bcl-2 homologous antagonist/killer" OR TITLE:"BCL2L7" OR ABSTRACT:"BCL2L7" OR TITLE:"CDN1" OR ABSTRACT:"CDN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BAK1, not a curated reading list.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.