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CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Required for anchoring microtubules to the centrosomes. Required for ciliation.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.23, genetic association 0.52, somatic mutation 0.49, animal model 0.40).
In plain words · CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
CEP43 (Centrosomal protein 43) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.
Required for anchoring microtubules to the centrosomes. Required for ciliation.
No product in this corpus aims at CEP43 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Popovici et al, Blood, 1999, "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Source.
Sources: HGNC HGNC:17012 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95684 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000213066 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.53, leukaemia 0.62 (GraphQL API, CC0))
Required for anchoring microtubules to the centrosomes. Required for ciliation. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 6q27 (HGNC).
Query for this target: (TITLE:"CEP43" OR ABSTRACT:"CEP43" OR TITLE:"centrosomal protein 43" OR ABSTRACT:"centrosomal protein 43" OR TITLE:"Centrosomal protein 43" OR ABSTRACT:"Centrosomal protein 43" OR TITLE:"FGFR1OP" OR ABSTRACT:"FGFR1OP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CEP43, not a curated reading list.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.