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MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.63, affected pathway 0.97, genetic association 0.00, somatic mutation 0.23).
In plain words · MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
No product in this corpus aims at MYO18A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Chang N.-S. et al, Biochem. Biophys. Res. Commun, 1998, "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Source.
Sources: HGNC HGNC:31104 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95411 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196535 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0))
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).
Query for this target: (TITLE:"MYO18A" OR ABSTRACT:"MYO18A" OR TITLE:"myosin XVIIIA" OR ABSTRACT:"myosin XVIIIA" OR TITLE:"Putative TGFB1-induced anti-apoptotic factor 1" OR ABSTRACT:"Putative TGFB1-induced anti-apoptotic factor 1" OR TITLE:"KIAA0216" OR ABSTRACT:"KIAA0216" OR TITLE:"MysPDZ" OR ABSTRACT:"MysPDZ" OR TITLE:"TIAF1" OR ABSTRACT:"TIAF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYO18A, not a curated reading list.