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MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MYO18A" OR ABSTRACT:"MYO18A" OR TITLE:"myosin XVIIIA" OR ABSTRACT:"myosin XVIIIA" OR TITLE:"Putative TGFB1-induced anti-apoptotic factor 1" OR ABSTRACT:"Putative TGFB1-induced anti-apoptotic factor 1" OR TITLE:"KIAA0216" OR ABSTRACT:"KIAA0216" OR TITLE:"MysPDZ" OR ABSTRACT:"MysPDZ" OR TITLE:"TIAF1" OR ABSTRACT:"TIAF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYO18A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/myo18a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/myo18a.json. Licence CC BY-NC 4.0.