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CPSF6 (Cleavage and polyadenylation specificity factor subunit 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.94, genetic association 0.00).
In plain words · CPSF6 (Cleavage and polyadenylation specificity factor subunit 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
CPSF6 (Cleavage and polyadenylation specificity factor subunit 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.
No product in this corpus aims at CPSF6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Fleischhauer K.L., 1995. Source.
Sources: HGNC HGNC:13871 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16630 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000111605 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: leukaemia 0.52 (GraphQL API, CC0))
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localised in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localised upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle; Cytoplasm (UniProt). Locus 12q15 (HGNC).
Query for this target: (TITLE:"CPSF6" OR ABSTRACT:"CPSF6" OR TITLE:"cleavage and polyadenylation specific factor 6" OR ABSTRACT:"cleavage and polyadenylation specific factor 6" OR TITLE:"Cleavage and polyadenylation specificity factor subunit 6" OR ABSTRACT:"Cleavage and polyadenylation specificity factor subunit 6" OR TITLE:"HPBRII-4" OR ABSTRACT:"HPBRII-4" OR TITLE:"HPBRII-7" OR ABSTRACT:"HPBRII-7" OR TITLE:"CFIM68" OR ABSTRACT:"CFIM68") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CPSF6, not a curated reading list.