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LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signalling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Location: Nucleus; Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"LRRFIP1" OR ABSTRACT:"LRRFIP1" OR TITLE:"LRR binding FLII interacting protein 1" OR ABSTRACT:"LRR binding FLII interacting protein 1" OR TITLE:"Leucine-rich repeat flightless-interacting protein 1" OR ABSTRACT:"Leucine-rich repeat flightless-interacting protein 1" OR TITLE:"FLAP-1" OR ABSTRACT:"FLAP-1" OR TITLE:"FLIIAP1" OR ABSTRACT:"FLIIAP1" OR TITLE:"GCF-2" OR ABSTRACT:"GCF-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRRFIP1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/lrrfip1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/lrrfip1.json. Licence CC BY-NC 4.0.