{"entity":{"id":"rps29","kind":"target","name":"RPS29","aka":["ribosomal protein S29","Small ribosomal subunit protein uS14","S29","uS14"],"tldr":"RPS29 (Small ribosomal subunit protein uS14) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia and Myeloproliferative neoplasms.","summary":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.31, clinical 0.11, genetic literature 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10419","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10419"},{"label":"UniProt P62273","url":"https://www.uniprot.org/uniprotkb/P62273/entry"},{"label":"NCBI Gene 6235","url":"https://www.ncbi.nlm.nih.gov/gene/6235"},{"label":"Ensembl ENSG00000213741","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213741"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RPS29","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10419","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10419","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62273","url":"https://www.uniprot.org/uniprotkb/P62273/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000213741","url":"https://platform.opentargets.org/target/ENSG00000213741/associations","note":"association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.52, leukaemia 0.53 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"few-types","specificityNote":"Broadly expressed or essential: HPA lists RPS29 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RPS29: RNA low tissue specificity; high antibody staining in 12 normal tissues; highest cancer staining colorectal cancer (2 of 10 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Leukaemia, Myeloid neoplasms); Open Targets associates it with 1 specific cancer type at or above 0.5 (Diamond-Blackfan anemia). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RPS29 tissue","url":"https://www.proteinatlas.org/ENSG00000213741-RPS29/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000213741 associations","url":"https://platform.opentargets.org/target/ENSG00000213741/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:10419","ensembl":"ENSG00000213741","uniprot":"P62273","entrez":"6235","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Frigerio J.-M. et al, Biochim. Biophys. Acta, 1995, \"Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7772601/","biology":"Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 14q21.3 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076)"],"targetClass":"other","prevalence":[]},"route":"/targets/rps29/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}