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ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.92, genetic association 0.51, somatic mutation 0.90, animal model 0.32).
In plain words · ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria.
No product in this corpus aims at ARHGAP26 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:17073 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UNA1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145819 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.55, skin cancer 0.51, myeloproliferative neoplasm 0.52, breast cancer 0.54, leukaemia 0.54 (GraphQL API, CC0))
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).
Query for this target: (TITLE:"ARHGAP26" OR ABSTRACT:"ARHGAP26" OR TITLE:"Rho GTPase activating protein 26" OR ABSTRACT:"Rho GTPase activating protein 26" OR TITLE:"Rho GTPase-activating protein 26" OR ABSTRACT:"Rho GTPase-activating protein 26" OR TITLE:"KIAA0621" OR ABSTRACT:"KIAA0621" OR TITLE:"OPHN1L" OR ABSTRACT:"OPHN1L" OR TITLE:"OPHN1L1" OR ABSTRACT:"OPHN1L1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGAP26, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Breast cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Breast cancer (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Breast cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Open Targets Platform.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Breast cancer (all types).