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ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ARHGAP26" OR ABSTRACT:"ARHGAP26" OR TITLE:"Rho GTPase activating protein 26" OR ABSTRACT:"Rho GTPase activating protein 26" OR TITLE:"Rho GTPase-activating protein 26" OR ABSTRACT:"Rho GTPase-activating protein 26" OR TITLE:"KIAA0621" OR ABSTRACT:"KIAA0621" OR TITLE:"OPHN1L" OR ABSTRACT:"OPHN1L" OR TITLE:"OPHN1L1" OR ABSTRACT:"OPHN1L1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGAP26, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/arhgap26.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/arhgap26.json. Licence CC BY-NC 4.0.