{"entity":{"id":"arhgap26","kind":"target","name":"ARHGAP26","aka":["Rho GTPase activating protein 26","Rho GTPase-activating protein 26","KIAA0621","OPHN1L","OPHN1L1"],"tldr":"ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.","summary":"GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.92, genetic association 0.51, somatic mutation 0.90, animal model 0.32).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17073"},{"label":"UniProt Q9UNA1","url":"https://www.uniprot.org/uniprotkb/Q9UNA1/entry"},{"label":"NCBI Gene 23092","url":"https://www.ncbi.nlm.nih.gov/gene/23092"},{"label":"Ensembl ENSG00000145819","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145819"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["gastric","breast-cancer","leukaemia","myeloproliferative-neoplasms","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ARHGAP26","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:17073","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17073","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UNA1","url":"https://www.uniprot.org/uniprotkb/Q9UNA1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000145819","url":"https://platform.opentargets.org/target/ENSG00000145819/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.55, skin cancer 0.51, myeloproliferative neoplasm 0.52, breast cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:17073","ensembl":"ENSG00000145819","uniprot":"Q9UNA1","entrez":"23092","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9734811/","biology":"GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)"],"targetClass":"other","prevalence":[]},"route":"/targets/arhgap26/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}