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LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites.
Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.93, animal model 0.56, genetic association 0.79, somatic mutation 0.98).
In plain words · LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription.
No product in this corpus aims at LPP yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Petit M.M.R. et al, Genomics, 1996, "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family". Source.
Sources: HGNC HGNC:6679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93052 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145012 (association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: gastric cancer 0.50, neuroendocrine neoplasm 0.50, non-Hodgkin lymphoma 0.52, skin cancer 0.63, basal cell carcinoma 0.57, breast cancer 0.57 (GraphQL API, CC0))
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Location: Nucleus; Cytoplasm; Cell junction; Cell membrane (UniProt). Locus 3q27.3-q28 (HGNC).
Query for this target: (TITLE:"LPP" OR ABSTRACT:"LPP" OR TITLE:"LIM domain containing preferred translocation partner in lipoma" OR ABSTRACT:"LIM domain containing preferred translocation partner in lipoma" OR TITLE:"Lipoma-preferred partner" OR ABSTRACT:"Lipoma-preferred partner") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LPP, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).