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STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.90).
In plain words · STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
STIL (SCL-interrupting locus protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Skin cancer and Leukaemia.
Immediate-early gene.
No product in this corpus aims at STIL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1991. Earliest sequence paper UniProt cites for the protein: Aplan P.D. et al, Mol. Cell. Biol, 1991, "Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia". Source.
Sources: HGNC HGNC:10879 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15468 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123473 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.55, skin cancer 0.52, leukaemia 0.51 (GraphQL API, CC0))
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cell cortex (UniProt). Locus 1p33 (HGNC).
Query for this target: (TITLE:"STIL" OR ABSTRACT:"STIL" OR TITLE:"STIL centriolar assembly protein" OR ABSTRACT:"STIL centriolar assembly protein" OR TITLE:"SCL-interrupting locus protein" OR ABSTRACT:"SCL-interrupting locus protein" OR TITLE:"MCPH7" OR ABSTRACT:"MCPH7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STIL, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.