Loading
FANCF (Fanconi anaemia group F protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Skin cancer and Melanoma.
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.83, affected pathway 0.26, literature 0.94, genetic association 0.25, somatic mutation 0.93, animal model 0.49).
In plain words · FANCF (Fanconi anaemia group F protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Skin cancer and Melanoma.
FANCF (Fanconi anaemia group F protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Skin cancer and Melanoma.
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
No product in this corpus aims at FANCF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: de Winter J.P. et al, Nat. Genet, 2000, "The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM". Source.
Sources: HGNC HGNC:3587 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPI8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183161 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.50, leukaemia 0.60 (GraphQL API, CC0))
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Location: Nucleus (UniProt). Locus 11p14.3 (HGNC).
Query for this target: (TITLE:"FANCF" OR ABSTRACT:"FANCF" OR TITLE:"FA complementation group F" OR ABSTRACT:"FA complementation group F" OR TITLE:"Fanconi anemia group F protein" OR ABSTRACT:"Fanconi anemia group F protein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCF, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.