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IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, animal model 0.54, genetic association 0.00, clinical 0.96).
In plain words · IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
No product in this corpus aims at IL2RG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA IL2RG: RNA tissue enhanced (intestine 109 nTPM, lymphoid tissue 318 nTPM); high antibody staining in 2 normal tissues. Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Renal cell carcinoma, Leukaemia, Lymphoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (primary cutaneous T-cell non-Hodgkin lymphoma, renal cell carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas IL2RG tissue; Open Targets ENSG00000147168 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Takeshita et al, Science, 1992, "Cloning of the gamma chain of the human IL-2 receptor". Source.
Sources: HGNC HGNC:6010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31785 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147168 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: renal cell carcinoma 0.54, melanoma 0.55, non-Hodgkin lymphoma 0.51, skin cancer 0.56, leukaemia 0.54, primary cutaneous T-cell non-Hodgkin lymphoma 0.55 (GraphQL API, CC0))
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane; Cell surface (UniProt). Locus Xq13.1 (HGNC).
RNA: tissue enhanced (intestine 109 nTPM, lymphoid tissue 318 nTPM), detected in many normal tissues.
Medium: Gallbladder, Spleen, Stomach.
No cancer stained high; medium in skin cancer.
HPA IL2RG tissue · HPA IL2RG pathology · HPA protein class: CD markers, FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IL2RG" OR ABSTRACT:"IL2RG" OR TITLE:"interleukin 2 receptor subunit gamma" OR ABSTRACT:"interleukin 2 receptor subunit gamma" OR TITLE:"Cytokine receptor common subunit gamma" OR ABSTRACT:"Cytokine receptor common subunit gamma" OR TITLE:"CD132" OR ABSTRACT:"CD132" OR TITLE:"SCIDX1" OR ABSTRACT:"SCIDX1" OR TITLE:"IMD4" OR ABSTRACT:"IMD4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL2RG, not a curated reading list.
Shares Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome), Leukaemia (all types), Renal cell carcinoma, Skin cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Renal cell carcinoma, Skin cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Melanoma, Open Targets Platform.