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CNOT3 (CCR4-NOT transcription complex subunit 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Leukaemia, Non-Hodgkin lymphoma and 4 more.
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.33, literature 0.72, genetic association 0.00, somatic mutation 0.84, animal model 0.25). IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Prostate Adenocarcinoma.
In plain words · CNOT3 (CCR4-NOT transcription complex subunit 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Leukaemia, Non-Hodgkin lymphoma and 4 more.
CNOT3 (CCR4-NOT transcription complex subunit 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Leukaemia, Non-Hodgkin lymphoma and 4 more.
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
No product in this corpus aims at CNOT3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:7879 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75175 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000088038 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: melanoma 0.55, acute lymphoblastic leukaemia 0.54, non-Hodgkin lymphoma 0.55, skin cancer 0.54, leukaemia 0.56 (GraphQL API, CC0)); IntOGen CNOT3 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. Location: Cytoplasm; Nucleus; Cytoplasm, P-body (UniProt). Locus 19q13.42 (HGNC).
Query for this target: (TITLE:"CNOT3" OR ABSTRACT:"CNOT3" OR TITLE:"CCR4-NOT transcription complex subunit 3" OR ABSTRACT:"CCR4-NOT transcription complex subunit 3" OR TITLE:"NOT3H" OR ABSTRACT:"NOT3H" OR TITLE:"KIAA0691" OR ABSTRACT:"KIAA0691" OR TITLE:"LENG2" OR ABSTRACT:"LENG2" OR TITLE:"NOT3" OR ABSTRACT:"NOT3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNOT3, not a curated reading list.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Chronic lymphocytic leukaemia, Skin cancer (all types), Acute lymphoblastic leukaemia.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), IntOGen, Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), Chronic lymphocytic leukaemia, Skin cancer (all types), IntOGen.