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MED12 (Mediator of RNA polymerase II transcription subunit 12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Cervical cancer, Endometrial cancer and 5 more.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.38, genetic association 0.19, somatic mutation 0.80). IntOGen calls it a driver in 14 cohorts (9 activating, 5 loss-of-function), covering Acute Lymphoblastic Leukaemia, Cervical Squamous Cell Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Glioblastoma Multiforme, Low-Grade Glioma, NOS, Neuroblastoma and others.
In plain words · MED12 (Mediator of RNA polymerase II transcription subunit 12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Cervical cancer, Endometrial cancer and 5 more.
MED12 (Mediator of RNA polymerase II transcription subunit 12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Cervical cancer, Endometrial cancer and 5 more.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.
No product in this corpus aims at MED12 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:11957 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93074 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184634 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: skin cancer 0.52, leukaemia 0.51 (GraphQL API, CC0)); IntOGen MED12 (driver in 14 cohorts (Act 9, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signalling pathway and SHH signalling pathway. Location: Nucleus (UniProt). Locus Xq13.1 (HGNC).
Query for this target: (TITLE:"MED12" OR ABSTRACT:"MED12" OR TITLE:"mediator complex subunit 12" OR ABSTRACT:"mediator complex subunit 12" OR TITLE:"Mediator of RNA polymerase II transcription subunit 12" OR ABSTRACT:"Mediator of RNA polymerase II transcription subunit 12" OR TITLE:"CAGH45" OR ABSTRACT:"CAGH45" OR TITLE:"OPA1" OR ABSTRACT:"OPA1" OR TITLE:"TRAP230" OR ABSTRACT:"TRAP230") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MED12, not a curated reading list.
Shares Leukaemia (all types), Chronic lymphocytic leukaemia, Skin cancer (all types), Acute lymphoblastic leukaemia.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Glioma & glioblastoma, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Cervical cancer, Acute lymphoblastic leukaemia.