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TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.64, somatic mutation 0.75). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
TAL1 (T-cell acute lymphocytic leukaemia protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Non-Hodgkin lymphoma, Skin cancer and 2 more.
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation.
No product in this corpus aims at TAL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Begley C.G. et al, Proc. Natl. Acad. Sci. U.S.A, 1989, "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif". Source.
Sources: HGNC HGNC:11556 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17542 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162367 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.52, non-Hodgkin lymphoma 0.56, skin cancer 0.52, leukaemia 0.52 (GraphQL API, CC0)); IntOGen TAL1 (driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Implicated in the genesis of haemopoietic malignancies. It may play an important role in haemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. Location: Nucleus (UniProt). Locus 1p33 (HGNC).
Query for this target: (TITLE:"TAL1" OR ABSTRACT:"TAL1" OR TITLE:"TAL bHLH transcription factor 1, erythroid differentiation factor" OR ABSTRACT:"TAL bHLH transcription factor 1, erythroid differentiation factor" OR TITLE:"T-cell acute lymphocytic leukemia protein 1" OR ABSTRACT:"T-cell acute lymphocytic leukemia protein 1" OR TITLE:"bHLHa17" OR ABSTRACT:"bHLHa17" OR TITLE:"TCL5" OR ABSTRACT:"TCL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAL1, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Hepatocellular carcinoma.
Shares Leukaemia (all types), Hepatocellular carcinoma, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Hepatocellular carcinoma.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).