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RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, somatic mutation 0.83, clinical 0.11). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Non-Hodgkin Lymphoma, Plasma Cell Myeloma.
In plain words · RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
RPL10 (Large ribosomal subunit protein uL16) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 1 more.
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes.
No product in this corpus aims at RPL10 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA RPL10: RNA low tissue specificity; high antibody staining in 40 normal tissues; highest cancer staining head and neck cancer (4 of 4 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma, Leukaemia); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P27635; IntOGen RPL10; Human Protein Atlas RPL10 tissue; Open Targets ENSG00000147403 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Dowdy S.F. et al, Nucleic Acids Res, 1991, "The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells". Source.
Sources: HGNC HGNC:10298 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P27635 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147403 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.50, non-Hodgkin lymphoma 0.58, leukaemia 0.52 (GraphQL API, CC0)); IntOGen RPL10 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Heart muscle, Skeletal muscle, Smooth muscle, Soft tissue.
Medium only: carcinoid.
HPA RPL10 tissue · HPA RPL10 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RPL10" OR ABSTRACT:"RPL10" OR TITLE:"ribosomal protein L10" OR ABSTRACT:"ribosomal protein L10" OR TITLE:"Large ribosomal subunit protein uL16" OR ABSTRACT:"Large ribosomal subunit protein uL16" OR TITLE:"DXS648E" OR ABSTRACT:"DXS648E" OR TITLE:"DXS648" OR ABSTRACT:"DXS648" OR TITLE:"FLJ23544" OR ABSTRACT:"FLJ23544") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPL10, not a curated reading list.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.