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LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.99, animal model 0.67, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway.
No product in this corpus aims at LEF1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1991. Earliest sequence paper UniProt cites for the protein: Waterman M.L. et al, Genes Dev, 1991, "A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer". Source.
Sources: HGNC HGNC:6551 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJU2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138795 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.59, non-Hodgkin lymphoma 0.59, skin cancer 0.53, breast cancer 0.52, leukaemia 0.61 (GraphQL API, CC0)); IntOGen LEF1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonises both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Location: Nucleus (UniProt). Locus 4q25 (HGNC).
Query for this target: (TITLE:"LEF1" OR ABSTRACT:"LEF1" OR TITLE:"lymphoid enhancer binding factor 1" OR ABSTRACT:"lymphoid enhancer binding factor 1" OR TITLE:"Lymphoid enhancer-binding factor 1" OR ABSTRACT:"Lymphoid enhancer-binding factor 1" OR TITLE:"TCF1ALPHA" OR ABSTRACT:"TCF1ALPHA" OR TITLE:"TCF10" OR ABSTRACT:"TCF10" OR TITLE:"TCF7L3" OR ABSTRACT:"TCF7L3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LEF1, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Hepatocellular carcinoma.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Hepatocellular carcinoma, IntOGen.
Shares Leukaemia (all types), Hepatocellular carcinoma, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Hepatocellular carcinoma.