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LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonises both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Location: Nucleus (UniProt). Locus 4q25 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"LEF1" OR ABSTRACT:"LEF1" OR TITLE:"lymphoid enhancer binding factor 1" OR ABSTRACT:"lymphoid enhancer binding factor 1" OR TITLE:"Lymphoid enhancer-binding factor 1" OR ABSTRACT:"Lymphoid enhancer-binding factor 1" OR TITLE:"TCF1ALPHA" OR ABSTRACT:"TCF1ALPHA" OR TITLE:"TCF10" OR ABSTRACT:"TCF10" OR TITLE:"TCF7L3" OR ABSTRACT:"TCF7L3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LEF1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/lef1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/lef1.json. Licence CC BY-NC 4.0.