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DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.54, literature 0.93, genetic association 0.00, somatic mutation 0.98, animal model 0.58).
In plain words · DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton.
No product in this corpus aims at DNM2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Diatloff-Zito et al, Gene, 1995, "Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family". Source.
Sources: HGNC HGNC:2974 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50570 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000079805 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51, breast cancer 0.51, leukaemia 0.58 (GraphQL API, CC0))
Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organisation of the actin cytoskeleton by mediating arrangement of stress fibres and actin bundles in podocytes. During organisation of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers. Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerisation of dynamin spiral polymers, and results in dispersion of actin bundles. Location: Cytoplasm, cytoskeleton; Cytoplasmic vesicle, clathrin-coated vesicle; Cell projection, uropodium; Endosome (UniProt). Locus 19p13.2 (HGNC).
Query for this target: (TITLE:"DNM2" OR ABSTRACT:"DNM2" OR TITLE:"dynamin 2" OR ABSTRACT:"dynamin 2" OR TITLE:"Dynamin-2" OR ABSTRACT:"Dynamin-2" OR TITLE:"DYNII" OR ABSTRACT:"DYNII" OR TITLE:"DYN2" OR ABSTRACT:"DYN2" OR TITLE:"CMTDIB" OR ABSTRACT:"CMTDIB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNM2, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.