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BLM (RecQ-like DNA helicase BLM) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Breast cancer and 4 more.
ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA.
Open Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes genetic literature 0.64, affected pathway 0.87, literature 0.97, genetic association 0.73, somatic mutation 0.97).
In plain words · BLM (RecQ-like DNA helicase BLM) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Breast cancer and 4 more.
BLM (RecQ-like DNA helicase BLM) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Breast cancer and 4 more.
ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction. Participates in DNA replication and repair.
No product in this corpus aims at BLM yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Ellis N.A. et al, Cell, 1995, "The Bloom's syndrome gene product is homologous to RecQ helicases". Source.
Sources: HGNC HGNC:1058 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P54132 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197299 (association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: colorectal cancer 0.62, ovarian cancer 0.58, endometrial cancer 0.53, non-Hodgkin lymphoma 0.51, skin cancer 0.54, breast cancer 0.61 (GraphQL API, CC0))
ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA. Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides. Location: Nucleus (UniProt). Locus 15q26.1 (HGNC).
Query for this target: (TITLE:"BLM" OR ABSTRACT:"BLM" OR TITLE:"BLM RecQ like helicase" OR ABSTRACT:"BLM RecQ like helicase" OR TITLE:"RecQ-like DNA helicase BLM" OR ABSTRACT:"RecQ-like DNA helicase BLM" OR TITLE:"RECQL3" OR ABSTRACT:"RECQL3" OR TITLE:"RECQ2" OR ABSTRACT:"RECQ2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BLM, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Endometrial cancer, Skin cancer (all types), Ovarian cancer.
Shares Leukaemia (all types), Ovarian cancer, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Endometrial cancer, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Ovarian cancer, Breast cancer (all types), Non-Hodgkin lymphoma (all types).