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EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more.
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.35, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more.
EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more.
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation.
No product in this corpus aims at EPS15 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1994. Earliest sequence paper UniProt cites for the protein: Wong W.T. et al, Oncogene, 1994, "The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32". Source.
Sources: HGNC HGNC:3419 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P42566 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000085832 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.52, skin cancer 0.51, breast cancer 0.53, leukaemia 0.51 (GraphQL API, CC0)); IntOGen EPS15 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Location: Cytoplasm; Cell membrane; Membrane, clathrin-coated pit; Early endosome membrane (UniProt). Locus 1p32.3 (HGNC).
Query for this target: (TITLE:"EPS15" OR ABSTRACT:"EPS15" OR TITLE:"epidermal growth factor receptor pathway substrate 15" OR ABSTRACT:"epidermal growth factor receptor pathway substrate 15" OR TITLE:"Epidermal growth factor receptor substrate 15" OR ABSTRACT:"Epidermal growth factor receptor substrate 15" OR TITLE:"AF-1P" OR ABSTRACT:"AF-1P" OR TITLE:"MLLT5" OR ABSTRACT:"MLLT5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPS15, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), IntOGen, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), IntOGen, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.