Loading
SUZ12 (Polycomb protein SUZ12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Breast cancer, Prostate cancer and 4 more.
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes affected pathway 0.72, literature 0.94, genetic association 0.02, somatic mutation 0.89, animal model 0.54). IntOGen calls it a driver in 4 cohorts (2 activating, 2 loss-of-function), covering Acute Myeloid Leukaemia, Prostate Adenocarcinoma, Sarcoma, NOS.
In plain words · SUZ12 (Polycomb protein SUZ12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Breast cancer, Prostate cancer and 4 more.
SUZ12 (Polycomb protein SUZ12) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Breast cancer, Prostate cancer and 4 more.
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.
No product in this corpus aims at SUZ12 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1995, "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:17101 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15022 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178691 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: prostate cancer 0.51, sarcoma 0.53, non-Hodgkin lymphoma 0.52, skin cancer 0.52, breast cancer 0.61, leukaemia 0.61 (GraphQL API, CC0)); IntOGen SUZ12 (driver in 4 cohorts (Act 2, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).
Query for this target: (TITLE:"SUZ12" OR ABSTRACT:"SUZ12" OR TITLE:"SUZ12 polycomb repressive complex 2 subunit" OR ABSTRACT:"SUZ12 polycomb repressive complex 2 subunit" OR TITLE:"Polycomb protein SUZ12" OR ABSTRACT:"Polycomb protein SUZ12" OR TITLE:"JJAZ1" OR ABSTRACT:"JJAZ1" OR TITLE:"KIAA0160" OR ABSTRACT:"KIAA0160" OR TITLE:"CHET9" OR ABSTRACT:"CHET9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SUZ12, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Acute myeloid leukaemia, IntOGen.
Shares Leukaemia (all types), IntOGen, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Non-Hodgkin lymphoma (all types).