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RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Leukaemia, Hepatocellular carcinoma and 5 more.
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, animal model 0.30, genetic association 0.32, somatic mutation 0.87). IntOGen calls it a driver in 7 cohorts (4 activating, 3 loss-of-function), covering Hepatocellular Carcinoma, Low-Grade Glioma, NOS, Lung Squamous Cell Carcinoma, Melanoma, Prostate Adenocarcinoma, Small Cell Lung Cancer.
In plain words · RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Leukaemia, Hepatocellular carcinoma and 5 more.
RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Leukaemia, Hepatocellular carcinoma and 5 more.
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes.
No product in this corpus aims at RUNX1T1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1993. Earliest sequence paper UniProt cites for the protein: Miyoshi et al, EMBO J, 1993, "The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript". Source.
Sources: HGNC HGNC:1535 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06455 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000079102 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: melanoma 0.59, acute myeloid leukaemia 0.51, non-Hodgkin lymphoma 0.52, skin cancer 0.55, myeloproliferative neoplasm 0.52, breast cancer 0.54 (GraphQL API, CC0)); IntOGen RUNX1T1 (driver in 7 cohorts (Act 4, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukaemic cells is involved in leukemogenesis and contributes to haematopoietic stem/progenitor cell self-renewal. Location: Nucleus (UniProt). Locus 8q21.3 (HGNC).
Query for this target: (TITLE:"RUNX1T1" OR ABSTRACT:"RUNX1T1" OR TITLE:"RUNX1 partner transcriptional co-repressor 1" OR ABSTRACT:"RUNX1 partner transcriptional co-repressor 1" OR TITLE:"MTG8" OR ABSTRACT:"MTG8" OR TITLE:"ZMYND2" OR ABSTRACT:"ZMYND2" OR TITLE:"AML1T1" OR ABSTRACT:"AML1T1" OR TITLE:"CBFA2T1" OR ABSTRACT:"CBFA2T1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RUNX1T1, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Hepatocellular carcinoma, IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Hepatocellular carcinoma, IntOGen.