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EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Location: Cytoplasm; Cell membrane; Membrane, clathrin-coated pit; Early endosome membrane (UniProt). Locus 1p32.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"EPS15" OR ABSTRACT:"EPS15" OR TITLE:"epidermal growth factor receptor pathway substrate 15" OR ABSTRACT:"epidermal growth factor receptor pathway substrate 15" OR TITLE:"Epidermal growth factor receptor substrate 15" OR ABSTRACT:"Epidermal growth factor receptor substrate 15" OR TITLE:"AF-1P" OR ABSTRACT:"AF-1P" OR TITLE:"MLLT5" OR ABSTRACT:"MLLT5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPS15, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/eps15.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/eps15.json. Licence CC BY-NC 4.0.