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PRF1 (Perforin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 2 more.
Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognised as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerise and form large pores.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.91, animal model 0.52, genetic association 0.41, somatic mutation 0.97).
In plain words · PRF1 (Perforin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 2 more.
PRF1 (Perforin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Skin cancer and 2 more.
Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells.
No product in this corpus aims at PRF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1988. Earliest sequence paper UniProt cites for the protein: Lichtenheld M.G. et al, Nature, 1988, "Structure and function of human perforin". Source.
Sources: HGNC HGNC:9360 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14222 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000180644 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: gastric cancer 0.50, melanoma 0.53, non-Hodgkin lymphoma 0.68, skin cancer 0.55, leukaemia 0.63 (GraphQL API, CC0))
Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognised as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerise and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently. Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu. Location: Cytolytic granule; Secreted; Cell membrane; Endosome lumen (UniProt). Locus 10q22.1 (HGNC).
Query for this target: (TITLE:"PRF1" OR ABSTRACT:"PRF1" OR TITLE:"perforin 1" OR ABSTRACT:"perforin 1" OR TITLE:"Perforin-1" OR ABSTRACT:"Perforin-1" OR TITLE:"P1" OR ABSTRACT:"P1" OR TITLE:"HPLH2" OR ABSTRACT:"HPLH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRF1, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), Non-Hodgkin lymphoma (all types), Melanoma, Open Targets Platform.