Loading
KDM5A (Lysine-specific demethylase 5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Lung cancer and 3 more.
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Gallbladder Cancer.
In plain words · KDM5A (Lysine-specific demethylase 5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Lung cancer and 3 more.
KDM5A (Lysine-specific demethylase 5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Lung cancer and 3 more.
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.
No product in this corpus aims at KDM5A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1991. Earliest sequence paper UniProt cites for the protein: Defeo-Jones et al, Nature, 1991, "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product". Source.
Sources: HGNC HGNC:9886 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P29375 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000073614 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.52, skin cancer 0.55, lung cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)); IntOGen KDM5A (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. Location: Nucleus, nucleolus; Nucleus (UniProt). Locus 12p13.33 (HGNC).
Query for this target: (TITLE:"KDM5A" OR ABSTRACT:"KDM5A" OR TITLE:"lysine demethylase 5A" OR ABSTRACT:"lysine demethylase 5A" OR TITLE:"Lysine-specific demethylase 5A" OR ABSTRACT:"Lysine-specific demethylase 5A" OR TITLE:"RBBP2" OR ABSTRACT:"RBBP2" OR TITLE:"JARID1A" OR ABSTRACT:"JARID1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KDM5A, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Melanoma.
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Leukaemia (all types), IntOGen, Melanoma, Open Targets Platform.