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SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.98, genetic association 0.03, somatic mutation 0.83, animal model 0.38). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cervical Squamous Cell Carcinoma.
In plain words · SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition.
No product in this corpus aims at SND1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1995. Earliest sequence paper UniProt cites for the protein: Tong et al, Mol. Cell. Biol, 1995, "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Source.
Sources: HGNC HGNC:30646 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7KZF4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197157 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.52, non-Hodgkin lymphoma 0.52, breast cancer 0.56, lung cancer 0.54, leukaemia 0.51 (GraphQL API, CC0)); IntOGen SND1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. Location: Cytoplasm; Nucleus; Melanosome (UniProt). Locus 7q32.1 (HGNC).
Query for this target: (TITLE:"SND1" OR ABSTRACT:"SND1" OR TITLE:"staphylococcal nuclease and tudor domain containing 1" OR ABSTRACT:"staphylococcal nuclease and tudor domain containing 1" OR TITLE:"Staphylococcal nuclease domain-containing protein 1" OR ABSTRACT:"Staphylococcal nuclease domain-containing protein 1" OR TITLE:"TDRD11" OR ABSTRACT:"TDRD11" OR TITLE:"p100" OR ABSTRACT:"p100") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SND1, not a curated reading list.
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Leukaemia (all types), Cervical cancer, IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Lung cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), IntOGen, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Cervical cancer, IntOGen, Breast cancer (all types).
Shares Leukaemia (all types), IntOGen, Lung cancer (all types), Breast cancer (all types).