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PBX1 (Pre-B-cell leukaemia transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Lung cancer and 3 more.
Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8. Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein. Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.98, animal model 0.50, genetic association 0.00, somatic mutation 0.97).
In plain words · PBX1 (Pre-B-cell leukaemia transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Lung cancer and 3 more.
PBX1 (Pre-B-cell leukaemia transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Leukaemia, Lung cancer and 3 more.
Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8.
No product in this corpus aims at PBX1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1990. Earliest sequence paper UniProt cites for the protein: Kamps M.P. et al, Cell, 1990, "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Source.
Sources: HGNC HGNC:8632 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P40424 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185630 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.59, breast cancer 0.54, lung cancer 0.55, leukaemia 0.59 (GraphQL API, CC0))
Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8. Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein. Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4. Acts as a transcriptional activator of PF4 in complex with MEIS1. Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence. In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development. Location: Nucleus (UniProt). Locus 1q23.3 (HGNC).
Query for this target: (TITLE:"PBX1" OR ABSTRACT:"PBX1" OR TITLE:"PBX homeobox 1" OR ABSTRACT:"PBX homeobox 1" OR TITLE:"Pre-B-cell leukemia transcription factor 1" OR ABSTRACT:"Pre-B-cell leukemia transcription factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PBX1, not a curated reading list.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types), Open Targets Platform.