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NUP98 (Nuclear pore complex protein Nup98-Nup96) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Lung cancer, Leukaemia and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localisation of DHX9 in discrete intranuclear foci (GLFG-body). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). Location: Nucleus membrane; Nucleus, nuclear pore complex; Nucleus, nucleoplasm (UniProt). Locus 11p15.4 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"NUP98" OR ABSTRACT:"NUP98" OR TITLE:"nucleoporin 98 and 96 precursor" OR ABSTRACT:"nucleoporin 98 and 96 precursor" OR TITLE:"Nuclear pore complex protein Nup98-Nup96" OR ABSTRACT:"Nuclear pore complex protein Nup98-Nup96" OR TITLE:"NUP96" OR ABSTRACT:"NUP96" OR TITLE:"Nup98-Nup96" OR ABSTRACT:"Nup98-Nup96" OR TITLE:"Nup98-96" OR ABSTRACT:"Nup98-96") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUP98, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/nup98.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nup98.json. Licence CC BY-NC 4.0.