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EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression.
Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes clinical 0.99, affected pathway 0.94, literature 0.98, genetic association 0.41, somatic mutation 0.98).
In plain words · EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
EML4 (Echinoderm microtubule-associated protein-like 4) is a gene. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer and Non-small-cell lung cancer.
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs.
No product in this corpus aims at EML4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Tumour-specific alteration: the catalogues call it a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA EML4: RNA low tissue specificity; high antibody staining in 26 normal tissues; highest cancer staining colorectal cancer (9 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Thyroid cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (non-small cell lung carcinoma). (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q9HC35; Human Protein Atlas EML4 tissue; Open Targets ENSG00000143924 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Heidebrecht H.J. et al, Genomics, 2000, "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein". Source.
Sources: HGNC HGNC:1316 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HC35 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143924 (association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.75, thyroid cancer 0.55, lung cancer 0.76 (GraphQL API, CC0))
Essential for the formation and stability of microtubules (MTs). Required for the organisation of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression. Location: Cytoplasm, cytoskeleton; Cytoplasm; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, microtubule organizing center (UniProt). Locus 2p21 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Breast, Bronchus, Caudate, Cerebral cortex, Epididymis, Esophagus, Fallopian tube, Nasopharynx.
Medium only: breast cancer, carcinoid, melanoma, skin cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EML4" OR ABSTRACT:"EML4" OR TITLE:"EMAP like 4" OR ABSTRACT:"EMAP like 4" OR TITLE:"Echinoderm microtubule-associated protein-like 4" OR ABSTRACT:"Echinoderm microtubule-associated protein-like 4" OR TITLE:"ROPP120" OR ABSTRACT:"ROPP120" OR TITLE:"ELP120" OR ABSTRACT:"ELP120" OR TITLE:"C2orf2" OR ABSTRACT:"C2orf2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EML4, not a curated reading list.
Shares Thyroid cancer, Lung cancer (all types), Open Targets Platform.
Shares Thyroid cancer, Lung cancer (all types), Open Targets Platform, Non-small-cell lung cancer.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.