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NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.94).
In plain words · NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis.
No product in this corpus aims at NCOA4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1994. Earliest sequence paper UniProt cites for the protein: Santoro et al, Oncogene, 1994, "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Source.
Sources: HGNC HGNC:7671 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13772 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000266412 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: thyroid cancer 0.54 (GraphQL API, CC0))
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Another study shows only weak behaviour as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR. Location: Cytoplasmic vesicle, autophagosome; Autolysosome; Nucleus; Chromosome (UniProt). Locus 10q11.22 (HGNC).
Query for this target: (TITLE:"NCOA4" OR ABSTRACT:"NCOA4" OR TITLE:"nuclear receptor coactivator 4" OR ABSTRACT:"nuclear receptor coactivator 4" OR TITLE:"Nuclear receptor coactivator 4" OR ABSTRACT:"Nuclear receptor coactivator 4" OR TITLE:"ARA70" OR ABSTRACT:"ARA70" OR TITLE:"ELE1" OR ABSTRACT:"ELE1" OR TITLE:"PTC3" OR ABSTRACT:"PTC3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOA4, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.