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TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.95, animal model 0.59, genetic association 0.72, somatic mutation 0.23).
In plain words · TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
TG (Thyroglobulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
No product in this corpus aims at TG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1985. Earliest sequence paper UniProt cites for the protein: Malthiery et al, Eur. J. Biochem, 1985, "Sequence of the 5'-end quarter of the human-thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence". Source.
Sources: HGNC HGNC:11764 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01266 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000042832 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: thyroid cancer 0.55 (GraphQL API, CC0))
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalisation and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Location: Secreted (UniProt). Locus 8q24.22 (HGNC).
Query for this target: (TITLE:"TG" OR ABSTRACT:"TG" OR TITLE:"thyroglobulin" OR ABSTRACT:"thyroglobulin" OR TITLE:"Thyroglobulin" OR ABSTRACT:"Thyroglobulin" OR TITLE:"AITD3" OR ABSTRACT:"AITD3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TG, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.