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THRB (Thyroid hormone receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.95, animal model 0.75, genetic association 0.46, clinical 0.91).
In plain words · THRB (Thyroid hormone receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
THRB (Thyroid hormone receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
No product in this corpus aims at THRB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA THRB: RNA low tissue specificity; blood lineage group enriched (B-cells 2 nTPM, granulocytes 7 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (differentiated thyroid carcinoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas THRB tissue; Open Targets ENSG00000151090 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Weinberger et al, Cold Spring Harb. Symp. Quant. Biol, 1986, "Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins". Source.
Sources: HGNC HGNC:11799 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10828 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000151090 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: thyroid cancer 0.58 (GraphQL API, CC0))
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Location: Nucleus (UniProt). Locus 3p24.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: group enriched (B-cells 2 nTPM, granulocytes 7 nTPM).
No normal tissue stained high; medium in Testis.
No cancer stained high; medium in carcinoid, colorectal cancer, liver cancer, pancreatic cancer.
HPA THRB tissue · HPA THRB pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"THRB" OR ABSTRACT:"THRB" OR TITLE:"thyroid hormone receptor beta" OR ABSTRACT:"thyroid hormone receptor beta" OR TITLE:"Thyroid hormone receptor beta" OR ABSTRACT:"Thyroid hormone receptor beta" OR TITLE:"THRB1" OR ABSTRACT:"THRB1" OR TITLE:"THRB2" OR ABSTRACT:"THRB2" OR TITLE:"NR1A2" OR ABSTRACT:"NR1A2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about THRB, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.