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SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.68, animal model 0.44, genetic association 0.70).
In plain words · SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Plays a role in the establishment of cell polarity and epithelial lumen formation.
No product in this corpus aims at SDCCAG8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Scanlan M.J. et al, Int. J. Cancer, 1998, "Characterization of human colon cancer antigens recognized by autologous antibodies". Source.
Sources: HGNC HGNC:10671 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86SQ7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000054282 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: thyroid cancer 0.53 (GraphQL API, CC0))
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body; Cell junction (UniProt). Locus 1q43-q44 (HGNC).
Query for this target: (TITLE:"SDCCAG8" OR ABSTRACT:"SDCCAG8" OR TITLE:"SHH signaling and ciliogenesis regulator SDCCAG8" OR ABSTRACT:"SHH signaling and ciliogenesis regulator SDCCAG8" OR TITLE:"Serologically defined colon cancer antigen 8" OR ABSTRACT:"Serologically defined colon cancer antigen 8" OR TITLE:"NY-CO-8" OR ABSTRACT:"NY-CO-8" OR TITLE:"CCCAP" OR ABSTRACT:"CCCAP" OR TITLE:"SLSN7" OR ABSTRACT:"SLSN7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDCCAG8, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.