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MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.71, somatic mutation 0.55, genetic literature 0.61).
In plain words · MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates.
No product in this corpus aims at MINPP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1999. Earliest sequence paper UniProt cites for the protein: Caffrey J.J. et al, FEBS Lett, 1999, "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification". Source.
Sources: HGNC HGNC:7102 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UNW1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107789 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: thyroid cancer 0.62 (GraphQL API, CC0))
Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolysing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of haemoglobin. Location: Endoplasmic reticulum lumen; Secreted; Cell membrane (UniProt). Locus 10q23.2 (HGNC).
Query for this target: (TITLE:"MINPP1" OR ABSTRACT:"MINPP1" OR TITLE:"multiple inositol-polyphosphate phosphatase 1" OR ABSTRACT:"multiple inositol-polyphosphate phosphatase 1" OR TITLE:"Multiple inositol polyphosphate phosphatase 1" OR ABSTRACT:"Multiple inositol polyphosphate phosphatase 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MINPP1, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.